ABC44

Names

[ Name ]:
ABC44

[Synonym ]:
ABC44
Imidazo[1,5-a]pyrazine-1,3(2H,5H)-dione, tetrahydro-2-[[[4-(4-methoxyphenyl)-1-piperazinyl]carbonyl]oxy]-7-[[1-(phenylmethyl)-4-piperidinyl]methyl]-
7-[(1-Benzyl-4-piperidinyl)methyl]-2-({[4-(4-methoxyphenyl)-1-piperazinyl]carbonyl}oxy)tetrahydroimidazo[1,5-a]pyrazine-1,3(2H,5H)-dione
7-((1-Benzylpiperidin-4-yl)methyl)-1,3-dioxohexahydroimidazo[1,5-a]pyrazin-2(3H)-yl 4-(4-methoxyphenyl)piperazine-1-carboxylate
4-(4-Methoxyphenyl)-1-piperazinecarboxylic acid hexahydro-1,3-dioxo-7-[[1-(phenylmethyl)-4-piperidinyl]methyl]imidazo[1,5-a]pyrazin-2-yl ester

Biological Activity

[Description]:

ABC44 is a potent serine hydrolase inhibitor with IC50s of 0.1 μM and 6.5 μM for palmitoyl protein thioesterase 1 (PPT1) in situ and in vitro, respectively. ABC44 can be used for researching infantile neuronal ceroid lipofuscinosis[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[Target]

IC50: 0.1 μM (PPT1 in situ), 6.5 μM (PPT1 in vitro)[1]

[References]

[1]. Cognetta AB 3rd, Niphakis MJ, Lee HC, Martini ML, Hulce JJ, Cravatt BF. Selective N-Hydroxyhydantoin Carbamate Inhibitors of Mammalian Serine Hydrolases. Chem Biol. 2015 Jul 23;22(7):928-37.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
689.8±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃₁H₄₀N₆O₅

[ Molecular Weight ]:
576.687

[ Flash Point ]:
371.0±34.3 °C

[ Exact Mass ]:
576.306030

[ LogP ]:
1.75

[ Vapour Pressure ]:
0.0±2.2 mmHg at 25°C

[ Index of Refraction ]:
1.669

Related Compounds

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