1831135-46-6

1831135-46-6 structure

Name: ABC44
Chemical Name: ABC44
CAS Number: 1831135-46-6
Molecular Formula: C₃₁H₄₀N₆O₅
Molecular Weight: 576.687
Catalog: Research Areas Neurological Disease
Create Date: 2021-01-08 13:53:37
Modify Date: 2025-08-27 11:45:48
ABC44 is a potent serine hydrolase inhibitor with IC50s of 0.1 μM and 6.5 μM for palmitoyl protein thioesterase 1 (PPT1) in situ and in vitro, respectively. ABC44 can be used for researching infantile neuronal ceroid lipofuscinosis[1].

Name	ABC44
Synonyms	ABC44 Imidazo[1,5-a]pyrazine-1,3(2H,5H)-dione, tetrahydro-2-[[[4-(4-methoxyphenyl)-1-piperazinyl]carbonyl]oxy]-7-[[1-(phenylmethyl)-4-piperidinyl]methyl]- 7-[(1-Benzyl-4-piperidinyl)methyl]-2-({[4-(4-methoxyphenyl)-1-piperazinyl]carbonyl}oxy)tetrahydroimidazo[1,5-a]pyrazine-1,3(2H,5H)-dione 7-((1-Benzylpiperidin-4-yl)methyl)-1,3-dioxohexahydroimidazo[1,5-a]pyrazin-2(3H)-yl 4-(4-methoxyphenyl)piperazine-1-carboxylate 4-(4-Methoxyphenyl)-1-piperazinecarboxylic acid hexahydro-1,3-dioxo-7-[[1-(phenylmethyl)-4-piperidinyl]methyl]imidazo[1,5-a]pyrazin-2-yl ester

Description	ABC44 is a potent serine hydrolase inhibitor with IC50s of 0.1 μM and 6.5 μM for palmitoyl protein thioesterase 1 (PPT1) in situ and in vitro, respectively. ABC44 can be used for researching infantile neuronal ceroid lipofuscinosis[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
Target	IC50: 0.1 μM (PPT1 in situ), 6.5 μM (PPT1 in vitro)[1]
References	[1]. Cognetta AB 3rd, Niphakis MJ, Lee HC, Martini ML, Hulce JJ, Cravatt BF. Selective N-Hydroxyhydantoin Carbamate Inhibitors of Mammalian Serine Hydrolases. Chem Biol. 2015 Jul 23;22(7):928-37.