S-(-)-LISURIDE

Names

[ Name ]:
S-(-)-LISURIDE

[Synonym ]:
Lisurida
LISURIDE
3-[(6aR,9S)-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinoline-9-yl]-1,1-diethylurea
Methylergol Carbamide
Lisuridum
Lysuride
Lysurid

Biological Activity

[Description]:

Lisuride is an orally active dopamine D2 receptors agonist. Lisuride, as an ergot derivative, can be used for the research of Parkinson's disease, migraine, and high prolactin levels[1][2].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor

Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor

Research Areas >> Neurological Disease

[Target]

D2 Receptor

[In Vivo]

lisuride (30~100 μg/kg) decreases the rate of dopa formation[2].

[References]

[1]. Rinne UK. Lisuride, a dopamine agonist in the treatment of early Parkinson's disease. Neurology. 1989;39(3):336-339.

[2]. Kehr W. Effect of lisuride and other ergot derivatives on monoaminergic mechanisms in rat brain. Eur J Pharmacol. 1977;41(3):261-273.

Chemical & Physical Properties

[ Density]:
1.23g/cm3

[ Boiling Point ]:
603.4ºC at 760mmHg

[ Molecular Formula ]:
C₂₄H₃₂N₄O₅

[ Molecular Weight ]:
456.53500

[ Flash Point ]:
318.7ºC

[ Exact Mass ]:
456.23700

[ PSA ]:
125.97000

[ LogP ]:
2.97230

[ Vapour Pressure ]:
1.9E-15mmHg at 25°C

[ Index of Refraction ]:
1.659

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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