PD150606

Names

[ Name ]:
PD150606

[Synonym ]:
(Z)-3-(4-iodophenyl)-2-mercaptoacrylic acid
PD150606
(2Z)-3-(4-Iodophenyl)-2-sulfanylacrylic acid
(2Z)-3-(4-iodophenyl)-2-sulfanylprop-2-enoic acid
2-Propenoic acid, 3-(4-iodophenyl)-2-mercapto-, (2Z)-

Biological Activity

[Description]:

PD 150606 is a selective, cell-permeable non-peptide calpain inhibitor (Ki values for ν and m-calpains are 0.21 and 0.37 μM respectively).target:calpain[1]In vitro: PD150606 also against tetrafluoroethyl-l-cysteine-, bromohydroquinone-, oxidant (t-butylhydroperoxide)- and calcium ionophore (ionomycin)-induced cell death. PD150606 inhibits calpains by binding to the calcium-binding domain of the enzyme. [2] high specificity for calpains relative to other proteases, uncompetitive inhibition with respect to substrate.[3]

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Proteasome

Research Areas >> Cancer

[References]

[1]. Squier MK et al. Calpain and calpastatin regulate neutrophil apoptosis. J Cell Physiol. 1999 Mar;178(3):311-9.

[2]. Waters SL et al. Calpains mediate calcium and chloride influx during the late phase of cell injury. J Pharmacol Exp Ther. 1997 Dec;283(3):1177-84.

[3]. Wang KK et al. An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective. Proc Natl Acad Sci U S A. 1996 Jun 25;93(13):6687-92.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.9±0.1 g/cm3

[ Boiling Point ]:
410.4±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₉H₇IO₂S

[ Molecular Weight ]:
306.120

[ Flash Point ]:
202.0±28.7 °C

[ Exact Mass ]:
305.921143

[ PSA ]:
76.10000

[ LogP ]:
4.25

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.732

[ Storage condition ]:
2-8℃

Safety Information

[ Symbol ]:

GHS05, GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H315-H317-H318-H335

[ Precautionary Statements ]:
P261-P280-P301 + P310-P305 + P351 + P338

[ RIDADR ]:
UN 2811 6.1 / PGIII

Articles

Improved performance of aminopropylsilatrane over aminopropyltriethoxysilane as an adhesive film for anchoring gold nanoparticles on silicon surfaces.

J. Nanosci. Nanotechnol. 9 , 2894-901, (2009)

Aminopropylsilatrane (AP-silatrane) was investigated as an adhesive layer for anchoring Au nanoparticles on silicon substrates. We compared the preparation procedure and film quality of the AP-silatra...