179528-45-1

179528-45-1 structure

Name: PD150606
Chemical Name: (Z)-3-(4-iodophenyl)-2-sulfanylprop-2-enoic acid
CAS Number: 179528-45-1
Molecular Formula: C₉H₇IO₂S
Molecular Weight: 306.120
Catalog: Signaling Pathways Metabolic Enzyme/Protease Proteasome
Create Date: 2018-10-13 18:58:25
Modify Date: 2024-01-02 16:55:53
PD 150606 is a selective, cell-permeable non-peptide calpain inhibitor (Ki values for ν and m-calpains are 0.21 and 0.37 μM respectively).target:calpain[1]In vitro: PD150606 also against tetrafluoroethyl-l-cysteine-, bromohydroquinone-, oxidant (t-butylhydroperoxide)- and calcium ionophore (ionomycin)-induced cell death. PD150606 inhibits calpains by binding to the calcium-binding domain of the enzyme. [2] high specificity for calpains relative to other proteases, uncompetitive inhibition with respect to substrate.[3]

Name	(Z)-3-(4-iodophenyl)-2-sulfanylprop-2-enoic acid
Synonyms	(Z)-3-(4-iodophenyl)-2-mercaptoacrylic acid PD150606 (2Z)-3-(4-Iodophenyl)-2-sulfanylacrylic acid (2Z)-3-(4-iodophenyl)-2-sulfanylprop-2-enoic acid 2-Propenoic acid, 3-(4-iodophenyl)-2-mercapto-, (2Z)-

Description	PD 150606 is a selective, cell-permeable non-peptide calpain inhibitor (Ki values for ν and m-calpains are 0.21 and 0.37 μM respectively).target:calpain[1]In vitro: PD150606 also against tetrafluoroethyl-l-cysteine-, bromohydroquinone-, oxidant (t-butylhydroperoxide)- and calcium ionophore (ionomycin)-induced cell death. PD150606 inhibits calpains by binding to the calcium-binding domain of the enzyme. [2] high specificity for calpains relative to other proteases, uncompetitive inhibition with respect to substrate.[3]
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Proteasome Research Areas >> Cancer
References	[1]. Squier MK et al. Calpain and calpastatin regulate neutrophil apoptosis. J Cell Physiol. 1999 Mar;178(3):311-9. [2]. Waters SL et al. Calpains mediate calcium and chloride influx during the late phase of cell injury. J Pharmacol Exp Ther. 1997 Dec;283(3):1177-84. [3]. Wang KK et al. An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective. Proc Natl Acad Sci U S A. 1996 Jun 25;93(13):6687-92.