Nociceptin(1-7)(Orphanin FQ(1-7))

Nociceptin (1-7) is the N-terminal bioactive fragment of nociceptin (HY-P0183). Nociceptin (1-7) is a potent ORL1 (NOP) receptor agonist with antinociceptive activity. Nociceptin (1-7) combines with nociceptin reduces hyperalgesia in vivo[1].

Signaling Pathways >> GPCR/G Protein >> Opioid Receptor

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Neuronal Signaling >> Opioid Receptor

Nociceptin (1-7) (intrathecal injection; 150–1200  nmol; single dose) has no significant effect in the nociceptive thermal threshold (hyperalgesia). However, when nociceptin (1–7) is injected simultaneously with nociceptin (3.0 fmol), nociceptin-induced hyperalgesia is significantly reduced[1]. Animal Model: Mice[1] Dosage: 150–1200  nmol Administration: Intrathecal injection; single dose Result: Co-treatment with nociceptin could reduce hyperalgesia.

[1]. T Sakurada, et al. Nociceptin (1 - 7) antagonizes nociceptin-induced hyperalgesia in mice.Br J Pharmacol. 1999 Nov;128(5):941-4.