4,4'-Iminodiphenol

Names

[ Name ]:
4,4'-Iminodiphenol

[Synonym ]:
Bis(4-hydroxyphenyl)amine
4,4'-dihydroxydiphenylamine
Phenol,4,4'-iminodi
Phenol,4,4'-iminobis
EINECS 217-136-3
Bis-(4-hydroxy-phenyl)-amin
4,4'-Imino-di-phenol
Bis(p-hydroxyphenyl)amine
4,4'-Iminobisphenol
leuco indophenol
4.4'-Dioxy-diphenylamin
4,4'-Azanediyldiphenol

Biological Activity

[Description]:

4-Propionamidophenol (compound 4a) is an inactive estrogen receptor ligand based on the diphenylamine skeleton[1].

[Related Catalog]:

Signaling Pathways >> Others >> Estrogen Receptor/ERR

Research Areas >> Others

[References]

[1]. Ohta, K., et al. Promising core structure for nuclear receptor ligands: Design and synthesis of novel estrogen receptor ligands based on diphenylamine skeleton. Bioorganic & Medicinal Chemistry Letters.2008;18(18), 5050–5053.

Chemical & Physical Properties

[ Density]:
1.32g/cm3

[ Boiling Point ]:
363ºC at 760mmHg

[ Molecular Formula ]:
C₁₂H₁₁NO₂

[ Molecular Weight ]:
201.22100

[ Flash Point ]:
158.8ºC

[ Exact Mass ]:
201.07900

[ PSA ]:
52.49000

[ LogP ]:
2.91440

[ Vapour Pressure ]:
8.88E-06mmHg at 25°C

[ Index of Refraction ]:
1.707

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SL5445000

CHEMICAL NAME :: Phenol, 4,4'-iminodi-

CAS REGISTRY NUMBER :: 1752-24-5

BEILSTEIN REFERENCE NO. :: 2104633

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C12-H11-N-O2

MOLECULAR WEIGHT :: 201.24

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 380 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 12,1123,1962

Safety Information

[ HS Code ]:
2922299090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922299090

[ Summary ]:
2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%