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Eleutherobin

Names

[ CAS No. ]:
174545-76-7

[ Name ]:
Eleutherobin

[Synonym ]:
eleutherobin

Biological Activity

[Description]:

Eleutherobin is a potent β-microtubule inhibitor with an IC50 value of 2 μM. Eleutherobin can be isolated from a marine soft coral. Eleutherobin has cytotoxic activity against cancer cells with similar potency to that of Paclitaxel (HY-B0015). Anticancer activity[1][2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin
Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin

[Target]

IC50: 2 μM (β-microtubule)[1]


[In Vitro]

Eleutherobin (0-600 nM; 72 h) exhibits cytotoxic activity against HCT116, HCT116 (VM46), A2780 and A2780/Tax22[1]. Cell Cytotoxicity Assay[1] Cell Line: HCT116, HCT116 (VM46), A2780 and A2780/Tax22 Concentration: 0-600 nM Incubation Time: 72 h Result: Exhibited cytotoxic activity against HCT116, HCT116 (VM46), A2780 and A2780/Tax22 with IC50s of 10.7 nM, 554 nM, 13.7 nM and 59 nM.

[References]

[1]. Long BH, et al. Eleutherobin, a novel cytotoxic agent that induces tubulin polymerization, is similar to paclitaxel (Taxol). Cancer Res. 1998 Mar 15;58(6):1111-5.

[2]. Xiao-Nan Jia, et al. Deep Learning Promotes the Screening of Natural Products with Potential Microtubule Inhibition Activity. American Chemical Society. 2022

Chemical & Physical Properties

[ Molecular Formula ]:
C35H48N2O10

[ Molecular Weight ]:
656.76300

[ Exact Mass ]:
656.33100

[ PSA ]:
147.80000

[ LogP ]:
3.24400

Related Compounds