Poloxime

Names

[ Name ]:
Poloxime

[Synonym ]:
2-methyl-5-(i-propyl)furan
5-methyl-2-isopropylfuran
2-isopropyl-5-methyl-p-benzoquinone 4-oxime
Furan,2-methyl-5-(1-methylethyl)
2-methyl-5-isopropylfuran
2-Isopropyl-5-methyl-[1,4]benzochinon-4-oxim
5-methyl-2-(1-methylethyl)furan
Thymochinon-oxim-(1)
2-isopropyl-5-methyl-[1,4]benzoquinone-4-oxime
2-isopropyl-5-methyl furan
Poloxime

Biological Activity

[Description]:

Poloxime, a hydrolysis product of poloxin, is a non-ATP-competitive Plk1 inhibitor, with moderate Plk1 inhibitory activity.

[Related Catalog]:

Research Areas >> Cancer

[Target]

PLK1

[In Vitro]

Poloxime (100 μM) inhibits phosphopeptide binding to polo-box domain (PBD) of polo-like kinase 1 (Plk1)[2].

[References]

[1]. Liu M, et al. Identification of indole-3-carboxylic acids as non-ATP-competitive Polo-like kinase 1 (Plk1) inhibitors. Bioorg Med Chem Lett. 2015 Feb 1;25(3):431-4.

[2]. Yin Z, et al. Thymoquinone blocks pSer/pThr recognition by Plk1 Polo-box domain as a phosphate mimic. ACS Chem Biol. 2013 Feb 15;8(2):303-8.

[Related Small Molecules]

Volasertib (BI 6727) | BI 2536 | Centrinone | Rigosertib sodium | CFI-400945 | GSK461364 | GW843682X | TAK-960 | NMS-1286937 | Poloxin | LFM-A13 | Ro3280 | MLN0905 | SBE 13 hydrochloride | HMN-214

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₀H₁₃NO₂

[ Molecular Weight ]:
179.21600

[ Exact Mass ]:
179.09500

[ PSA ]:
49.66000

[ LogP ]:
1.92800

[ Storage condition ]:
2-8℃

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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