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  • Product Name: Poloxime
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Hot CAS#:
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17302-61-3

17302-61-3 structure
17302-61-3 structure
  • Name: Poloxime
  • Chemical Name: (4E)-4-(Hydroxyimino)-2-isopropyl-5-methyl-2,5-cyclohexadien-1-on e
  • CAS Number: 17302-61-3
  • Molecular Formula: C10H13NO2
  • Molecular Weight: 179.21600
  • Catalog: Research Areas Cancer
  • Create Date: 2017-12-11 14:03:58
  • Modify Date: 2024-01-31 10:13:54
  • Poloxime, a hydrolysis product of poloxin, is a non-ATP-competitive Plk1 inhibitor, with moderate Plk1 inhibitory activity.
Name (4E)-4-(Hydroxyimino)-2-isopropyl-5-methyl-2,5-cyclohexadien-1-on e
Synonyms 2-methyl-5-(i-propyl)furan
5-methyl-2-isopropylfuran
2-isopropyl-5-methyl-p-benzoquinone 4-oxime
Furan,2-methyl-5-(1-methylethyl)
2-methyl-5-isopropylfuran
2-Isopropyl-5-methyl-[1,4]benzochinon-4-oxim
5-methyl-2-(1-methylethyl)furan
Thymochinon-oxim-(1)
2-isopropyl-5-methyl-[1,4]benzoquinone-4-oxime
2-isopropyl-5-methyl furan
Poloxime
Description Poloxime, a hydrolysis product of poloxin, is a non-ATP-competitive Plk1 inhibitor, with moderate Plk1 inhibitory activity.
Related Catalog
Target

PLK1
In Vitro Poloxime (100 μM) inhibits phosphopeptide binding to polo-box domain (PBD) of polo-like kinase 1 (Plk1)[2].
References

[1]. Liu M, et al. Identification of indole-3-carboxylic acids as non-ATP-competitive Polo-like kinase 1 (Plk1) inhibitors. Bioorg Med Chem Lett. 2015 Feb 1;25(3):431-4.

[2]. Yin Z, et al. Thymoquinone blocks pSer/pThr recognition by Plk1 Polo-box domain as a phosphate mimic. ACS Chem Biol. 2013 Feb 15;8(2):303-8.
Molecular Formula C10H13NO2
Molecular Weight 179.21600
Exact Mass 179.09500
PSA 49.66000
LogP 1.92800
Storage condition 2-8℃
89-83-8 structure

89-83-8

~%

17302-61-3 structure

17302-61-3
Literature: Dwyer; Mellor; Trikojus Journal and Proceedings of the Royal Society of New South Wales, 1932 , vol. 66, p. 315,319
490-91-5 structure

490-91-5

~96%

17302-61-3 structure

17302-61-3
Literature: Rathore, R.; Kim, J. S.; Kochi, J. K. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 19 p. 2675 - 2684
1076-56-8 structure

1076-56-8

~%

17302-61-3 structure

17302-61-3
Literature: Klingstedt; Sundstroem Journal fuer Praktische Chemie (Leipzig), 1927 , vol. <2> 116, p. 311
4732-12-1 structure

4732-12-1

~%

17302-61-3 structure

17302-61-3
Literature: Klingstedt; Sundstroem Journal fuer Praktische Chemie (Leipzig), 1927 , vol. <2> 116, p. 311
142-82-5 structure

142-82-5
39870-46-7 structure

39870-46-7
74-89-5 structure

74-89-5

~%

17302-61-3 structure

17302-61-3
Literature: Hixon Journal of the American Chemical Society, 1923 , vol. 45, p. 2339
39870-46-7 structure

39870-46-7

~%

17302-61-3 structure

17302-61-3
Literature: Sherk American Journal of Pharmacy and the Sciences Supporting Public Health (1937-1978), vol. 93, p. 214 Chem. Zentralbl., 1921 , vol. 92, # III p. 595
7647-01-0 structure

7647-01-0
64-17-5 structure

64-17-5
490-91-5 structure

490-91-5

~%

17302-61-3 structure

17302-61-3
Literature: Goldschmidt; Schmid Chemische Berichte, 1884 , vol. 17, p. 2067

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title: CAS No. 17302-61-3 | Chemsrc address: https://www.chemsrc.com/en/baike/1119546.html

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