(R,S)-α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid HydrobromideSee: A611500

Names

[ Name ]:
(R,S)-α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid HydrobromideSee: A611500

[Synonym ]:
3-(3-Hydroxy-5-methyl-1,2-oxazol-4-yl)alanine hydrobromide (1:1)

Biological Activity

[Description]:

(RS)-AMPA ((±)-AMPA) hydrobromide is a glutamate analogue and a potent and selective excitatory neurotransmitter L-glutamic acid agonist. (RS)-AMPA hydrobromide does not interfere with binding sites for kainic acid or NMDA receptors[1][2].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> iGluR

Research Areas >> Neurological Disease

Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

[References]

[1]. Hösli L, et al. Effects of the glutamate analogue AMPA and its interaction with antagonists on cultured rat spinal and brain stem neurones. Neurosci Lett. 1983 Mar 28;36(1):59-62.

[2]. Sommer B, et al. Flip and flop: a cell-specific functional switch in glutamate-operated channels of the CNS. Science. 1990 Sep 28;249(4976):1580-5.

Chemical & Physical Properties

[ Melting Point ]:
205-208°C

[ Molecular Formula ]:
C₇H₁₁BrN₂O₄

[ Molecular Weight ]:
267.08

[ Exact Mass ]:
265.99000

[ PSA ]:
109.58000

[ LogP ]:
1.30140

Safety Information

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

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