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GS-493

Names

[ CAS No. ]:
1710337-31-7

[ Name ]:
GS-493

Biological Activity

[Description]:

GS-493 is a novel potent, selective SHP2 inhibitor with IC50 of 71±15 nM in enzyme assay; displays 29- and 45-fold selectivity against related SHP1 and PTP1B; blocks HGF-stimulated epithelial-mesenchymal transition of human pancreatic adenocarcinoma (HPAF) cells, and inhibits cell colony formation in the NSCLC cell line LXFA 526L in soft agar; inhibits tumor growth in murine xenograft model.

[References]

References 1. Grosskopf S, et al. ChemMedChem. 2015 May;10(5):815-26. View Related Products by Target Protein Phosphatase/PTP

Chemical & Physical Properties

[ Molecular Formula ]:
C21H14N6O8S

[ Molecular Weight ]:
510.437

Safety Information

[ Hazard Codes ]:
Xi


Related Compounds

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