Name | GS-493 |
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Description | GS-493 is a novel potent, selective SHP2 inhibitor with IC50 of 71±15 nM in enzyme assay; displays 29- and 45-fold selectivity against related SHP1 and PTP1B; blocks HGF-stimulated epithelial-mesenchymal transition of human pancreatic adenocarcinoma (HPAF) cells, and inhibits cell colony formation in the NSCLC cell line LXFA 526L in soft agar; inhibits tumor growth in murine xenograft model. |
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References | References 1. Grosskopf S, et al. ChemMedChem. 2015 May;10(5):815-26. View Related Products by Target Protein Phosphatase/PTP |
Molecular Formula | C21H14N6O8S |
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Molecular Weight | 510.437 |
Hazard Codes | Xi |
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