1710337-31-7
1710337-31-7 structure
- Name: GS-493
- Chemical Name: GS-493
- CAS Number: 1710337-31-7
- Molecular Formula: C21H14N6O8S
- Molecular Weight: 510.437
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphatase
- Create Date: 2020-01-19 07:20:15
- Modify Date: 2024-04-04 19:35:21
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GS-493 is a novel potent, selective SHP2 inhibitor with IC50 of 71±15 nM in enzyme assay; displays 29- and 45-fold selectivity against related SHP1 and PTP1B; blocks HGF-stimulated epithelial-mesenchymal transition of human pancreatic adenocarcinoma (HPAF) cells, and inhibits cell colony formation in the NSCLC cell line LXFA 526L in soft agar; inhibits tumor growth in murine xenograft model.
| Name | GS-493 |
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| Description | GS-493 is a novel potent, selective SHP2 inhibitor with IC50 of 71±15 nM in enzyme assay; displays 29- and 45-fold selectivity against related SHP1 and PTP1B; blocks HGF-stimulated epithelial-mesenchymal transition of human pancreatic adenocarcinoma (HPAF) cells, and inhibits cell colony formation in the NSCLC cell line LXFA 526L in soft agar; inhibits tumor growth in murine xenograft model. |
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| References | References 1. Grosskopf S, et al. ChemMedChem. 2015 May;10(5):815-26. View Related Products by Target Protein Phosphatase/PTP |
| Molecular Formula | C21H14N6O8S |
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| Molecular Weight | 510.437 |
| Hazard Codes | Xi |
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