Ro 60-0175 fumarate

Ro60-0175 fumarate is a potent and selective agonist of 5-HT2C receptor. Ro60-0175 fumarate reduces Cocaine self-administration, and the ability of Cocaine to reinstate responding after extinction of drug-seeking behavior[1].

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor

Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

5-HT2C Receptor

Ro60-0175 (1 mg/kg; s.c.) fumarate preserves the regularity of responding seen in control animals in drug-treated group, but drug-treated animals reach their break-points earlier[1]. Ro60-0175 (0.5 mg/kg (SB242084); 1 mg/kg (Ro60-0175); s.c., i.p.) fumarate reduces responding for cocaine and effect is reversed by SB242084[1]. Ro60-0175 (0.3, 1, and 3 mg/kg (Ro60-0175); 1 mg/kg (yohimbine); s.c.; i.p.) fumarate dose dependently attenuates the response increased by the yohimbine treatment alone relative to vehicle injection[1]. Ro60-0175 (0.5 mg/kg (SB242084); 1 mg/kg (Ro60-0175); 1 mg/kg (yohimbine); s.c.; i.p.) fumarate reduces responding and that this effect is prevented by SB242084 pretreatment[1]. Ro60-0175 (0.3, 1, and 3 mg/kg; s.c.) fumarate significantly reduces responding on the active lever in the reinstatement group[1]. Ro60-0175 (0.5 mg/kg SB242084; 1 mg/kg Ro60-0175; s.c.; i.p.) fumarate reduces responding compared to vehicle in the reinstatement group, and that this effect is prevented by pretreatment with SB242084. For responding on the inactive lever, there are no significant main effects or interactions[1].

[1]. Fletcher PJ, et al. The 5-HT2C receptor agonist Ro60-0175 reduces cocaine self-administration and reinstatement induced by the stressor yohimbine, and contextual cues. Neuropsychopharmacology. 2008;33(6):1402-1412.