Propargyl-PEG3-CH2COOH

Names

[ CAS No. ]:
1694731-93-5

[ Name ]:
Propargyl-PEG3-CH2COOH

Biological Activity

[Description]:

Propargyl-PEG3-CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[References]

[1]. Wurz RP, et al. A "Click Chemistry Platform" for the Rapid Synthesis of Bispecific Molecules for Inducing ProteinDegradation. J Med Chem. 2018 Jan 25;61(2):453-461.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₁H₁₈O₆

[ Molecular Weight ]:
246.26

[ Storage condition ]:
-20°C

Propargyl-PEG3-CH2COOH

Names

Biological Activity

Chemical & Physical Properties

Related Compounds