Propargyl-PEG3-NHS ester

Names

[ Name ]:
Propargyl-PEG3-NHS ester

[Synonym ]:
1-[(3-{2-[2-(2-Propyn-1-yloxy)ethoxy]ethoxy}propanoyl)oxy]-2,5-pyrrolidinedione
2,5-Pyrrolidinedione, 1-[1-oxo-3-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]propoxy]-
MFCD23726610

Biological Activity

[Description]:

Propargyl-PEG3-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

[Target]

Cleavable

[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

[References]

[1]. Earl F Albone, et al. Eribulin-based antibody-drug conjugates and methods of use. US20170252458A1.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
427.2±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₄H₁₉NO₇

[ Molecular Weight ]:
313.303

[ Flash Point ]:
212.1±31.5 °C

[ Exact Mass ]:
313.116150

[ LogP ]:
-1.96

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.507

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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