RS 67333 hydrochloride
Names
[ CAS No. ]:
168986-60-5
[ Name ]:
RS 67333 hydrochloride
Biological Activity
[Description]:
RS 67333 hydrochloride is a potent and selective 5-HT4 receptor (5-HT4R) partial agonist with a pKi of 8.7 in guinea-pig striatum. RS 67333 hydrochloride exhibits lower affinities at several other receptors including 5-HT1A, 5-HT1D, 5-HT2A, 5-HT2C, dopamine D1, D2 and muscarinic M1-M3 receptors. RS 67333 hydrochloride has neuroprotective effects, and can be used for Alzheimer's disease research[1].
[Related Catalog]:
[Target]
5-HT4 Receptor:8.7 (pKi)
[In Vitro]
RS 67333 hydrochloride does exhibit affinities for the sigma 1 (pKi = 8.9) and sigma 2 (pKi = 8.0) binding sites. At the 5-HT4 receptor mediating relaxation of the carbachol-precontracted oesophagus, RS 67333 hydrochloride acts as a potent (pEC50 of 8.4), partial agonists (intrinsic activities, with respect to 5-HT is 0.5) with respect to 5-HT[1].
[References]
Chemical & Physical Properties
[ Boiling Point ]:
502.3ºC at 760mmHg
[ Molecular Formula ]:
C19H30Cl2N2O2
[ Molecular Weight ]:
389.36000
[ Flash Point ]:
257.6ºC
[ Exact Mass ]:
388.16800
[ PSA ]:
55.56000
[ LogP ]:
5.72690
[ Vapour Pressure ]:
3.22E-10mmHg at 25°C
[ Storage condition ]:
-20°C
Safety Information
[ HS Code ]:
2933399090
Customs
[ HS Code ]: 2933399090
[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%