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Epi-galantamine

Names

[ CAS No. ]:
1668-85-5

[ Name ]:
Epi-galantamine

[Synonym ]:
(-)-epigalanthamine

Biological Activity

[Description]:

Epi-galantamine is a diastereomer of Galantamine. Epi-galantamine is an alkaloid isolated from the bulbs and flowers of Caucasian snowdrop (Galanthus woronowii). Epi-galantamine inhibits AChE with an EC50 of 45.7 μM[1][2][3].

[Related Catalog]:

Research Areas >> Neurological Disease
Signaling Pathways >> Neuronal Signaling >> AChE

[Target]

EC50: 45.7 μM (AChE)[1]


[References]

[1]. Thomsen T, et al. Stereoselectivity of cholinesterase inhibition by galanthamine and tolerance in humans. Eur J Clin Pharmacol. 1990;39(6):603-5.

[2]. Berkov S, et al. Rapid TLC/GC-MS identification of acetylcholinesterase inhibitors in alkaloid extracts. Phytochem Anal. 2008 Sep-Oct;19(5):411-9.

[3]. Maláková J, et al. High-performance liquid chromatographic method with UV photodiode-array, fluorescence and mass spectrometric detection for simultaneous determination of galantamine and its phase I metabolites in biological samples. J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Jun 15;853(1-2):265-74.

Chemical & Physical Properties

[ Density]:
1.28g/cm3

[ Boiling Point ]:
439.3ºC at 760 mmHg

[ Melting Point ]:
183-185ºC

[ Molecular Formula ]:
C17H21NO3

[ Molecular Weight ]:
287.35400

[ Flash Point ]:
219.5ºC

[ Exact Mass ]:
287.15200

[ PSA ]:
41.93000

[ LogP ]:
1.78820

[ Vapour Pressure ]:
1.71E-08mmHg at 25°C

[ Index of Refraction ]:
1.636

[ Storage condition ]:
-20°C

Safety Information

[ Hazard Codes ]:
T+

Precursor & DownStream

Precursor

DownStream

Related Compounds