Adrenotensin (human)

Names

[ Name ]:
Adrenotensin (human)

Biological Activity

[Description]:

Adrenotensin (human) (Pro-ADM-153-185 (human)) is a 153-185 fragment of precursor peptide of Adrenomedullin. Adrenomedullin (ADM) is a 52-amino acid multifunctional peptide, which belongs to the CGRP superfamily of vasoactive peptide hormones[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> CGRP Receptor

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Neuronal Signaling >> CGRP Receptor

[In Vitro]

人 Adrenotensin (ADM) 肽由单个基因编码，位于 11 号染色体上，由四个外显子和三个内含子组成。转录本的翻译产生了 185 个氨基酸的前体肽 prepro-ADM，随后通过切割 N-末端信号肽将其转化为 164 个氨基酸的 pro-ADM。Pro-ADM 被进一步加工成 proADM N-末端 20 肽 (PAMP)、中间区域 pro-ADM、肾上腺素紧张素 Pro-ADM-153-185 和未成熟的 ADM，即 ADM 的 C 末端甘氨酸延伸版本[1]。

[References]

[1]. Ria Schönauer, et al. Adrenomedullin-new perspectives of a potent peptide hormone. J Pept Sci. 2017 Jul;23(7-8):472-485.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₄₃H₂₂₄N₄₂O₄₃

[ Molecular Weight ]:
3219.56

Related Compounds

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