Tenofovir diphosphate

Names

[ Name ]:
Tenofovir diphosphate

[Synonym ]:
tenofovir diphosphate
TNV
PMPApp
PMPA diphosphate
TFVTP
Tenofovir-DP
[2-(6-AMINO-9H-PURIN-9-YL)-1-METHYLETHOXY]METHYL-TRIPHOSPHATE

Biological Activity

[Description]:

Tenofovir diphosphate (TFV-DP) is a competitive DNA polymerases inhibitor (with respect to dATP) and a substrate of HIV type 1 (HIV-1) reverse transcriptase (RT)[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Reverse Transcriptase

[Target]

DNA polymerases; HIV-1 reverse transcriptase[1]

[In Vitro]

Tenofovir diphosphate acts as an inhibitor of DNA pol. Tenofovir-diphosphate is a weak inhibitor of DNA polymerases (pol) α, δ, and ɛ, with values for the Ki for PMPApp (PMPAppKi) relative to the Km for dATP (dATPKm) of 10.2, 10.2, and 15.6, respectively[1].

[References]

[1]. Gabriel Birkus, et al. Tenofovir Diphosphate Is a Poor Substrate and a Weak Inhibitor of Rat DNA Polymerases Alpha, Delta, and epsilon. Antimicrob Agents Chemother. 2002 May;46(5):1610-3.

Chemical & Physical Properties

[ Molecular Formula ]:
C₉H₁₆N₅O₁₀P₃

[ Molecular Weight ]:
447.17200

[ Exact Mass ]:
447.01100

[ PSA ]:
258.87000

[ LogP ]:
0.76400

Related Compounds

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