Tenofovir diphosphate triethylamine

Names

[ CAS No. ]:
2122333-63-3

[ Name ]:
Tenofovir diphosphate triethylamine

Biological Activity

[Description]:

Tenofovir diphosphate triethylamine (TFV-DP triethylamine) is a competitive DNA polymerases inhibitor (with respect to dATP) and a substrate of HIV type 1 (HIV-1) reverse transcriptase (RT)[1].

[Related Catalog]:

Research Areas >> Infection
Research Areas >> Inflammation/Immunology
Signaling Pathways >> Anti-infection >> Reverse Transcriptase

[In Vitro]

Tenofovir diphosphate acts as an inhibitor of DNA pol. Tenofovir-diphosphate is a weak inhibitor of DNA polymerases (pol) α, δ, and ɛ, with values for the Ki for PMPApp (PMPAppKi) relative to the Km for dATP (dATPKm) of 10.2, 10.2, and 15.6, respectively[1].

[References]

[1]. Gabriel Birkus, et al. Tenofovir Diphosphate Is a Poor Substrate and a Weak Inhibitor of Rat DNA Polymerases Alpha, Delta, and epsilon. Antimicrob Agents Chemother. 2002 May;46(5):1610-3.

Chemical & Physical Properties

[ Molecular Formula ]:
C15H31N6O10P3

[ Molecular Weight ]:
548.36

Related Compounds