166403-66-3

166403-66-3 structure

Name: Tenofovir diphosphate
Chemical Name: [(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-[hydroxy(phosphonooxy)phosphoryl]oxyphosphinic acid
CAS Number: 166403-66-3
Molecular Formula: C₉H₁₆N₅O₁₀P₃
Molecular Weight: 447.17200
Catalog: Signaling Pathways Anti-infection Reverse Transcriptase
Create Date: 2016-01-17 01:37:44
Modify Date: 2024-01-16 10:22:55
Tenofovir diphosphate (TFV-DP) is a competitive DNA polymerases inhibitor (with respect to dATP) and a substrate of HIV type 1 (HIV-1) reverse transcriptase (RT)[1].

Name	[(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-[hydroxy(phosphonooxy)phosphoryl]oxyphosphinic acid
Synonyms	tenofovir diphosphate TNV PMPApp PMPA diphosphate TFVTP Tenofovir-DP [2-(6-AMINO-9H-PURIN-9-YL)-1-METHYLETHOXY]METHYL-TRIPHOSPHATE

Description	Tenofovir diphosphate (TFV-DP) is a competitive DNA polymerases inhibitor (with respect to dATP) and a substrate of HIV type 1 (HIV-1) reverse transcriptase (RT)[1].
Related Catalog	Signaling Pathways >> Anti-infection >> Reverse Transcriptase
Target	DNA polymerases; HIV-1 reverse transcriptase[1]
In Vitro	Tenofovir diphosphate acts as an inhibitor of DNA pol. Tenofovir-diphosphate is a weak inhibitor of DNA polymerases (pol) α, δ, and ɛ, with values for the Ki for PMPApp (PMPAppKi) relative to the Km for dATP (dATPKm) of 10.2, 10.2, and 15.6, respectively[1].
References	[1]. Gabriel Birkus, et al. Tenofovir Diphosphate Is a Poor Substrate and a Weak Inhibitor of Rat DNA Polymerases Alpha, Delta, and epsilon. Antimicrob Agents Chemother. 2002 May;46(5):1610-3.