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Epiblastin A

Names

[ CAS No. ]:
16470-02-3

[ Name ]:
Epiblastin A

[Synonym ]:
MFCD02947161
6-(3-Chlorophenyl)-2,4,7-pteridinetriamine
6-(3-Chlorophenyl)pteridine-2,4,7-Triamine
2,4,7-Triamino-6-(m-chlorophenyl)-pteridine
2,4,7-Pteridinetriamine, 6-(3-chlorophenyl)-
Epiblastin A

Biological Activity

[Description]:

Epiblastin A is an ATP competitive casein kinase 1 (CK1) inhibitor with IC50s of 8.9, 0.5, and 4.7 µM for CK1α, CK1δ, and CK1 ɛ, respectively. Epiblastin A induces reprogramming of epiblast stem cells into embryonic stem cells by inhibition of CK1[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Casein Kinase
Signaling Pathways >> Stem Cell/Wnt >> Casein Kinase

[References]

[1]. Andrei Ursu, et al. Epiblastin A Induces Reprogramming of Epiblast Stem Cells Into Embryonic Stem Cells by Inhibition of Casein Kinase 1. Cell Chem Biol. 2016 Apr 21;23(4):494-507.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
596.1±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C12H10ClN7

[ Molecular Weight ]:
287.708

[ Flash Point ]:
314.3±32.9 °C

[ Exact Mass ]:
287.068634

[ LogP ]:
1.90

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.821

[ Storage condition ]:
-20°C

Related Compounds