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DHODH-IN-5

Names

[ CAS No. ]:
1644156-56-8

[ Name ]:
DHODH-IN-5

Biological Activity

[Description]:

DHODH-IN-5 is a potent human dihydroorotate dehydrogenase (DHODH) inhibitor, with a pIC50 of 7.8 for human recombinant DHODH. DHODH-IN-5 inhibits measles virus replication, with a pMIC50 of 8.8[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis
Signaling Pathways >> Metabolic Enzyme/Protease >> Lactate Dehydrogenase

[References]

[1]. Munier-Lehmann H, et al. Original 2-(3-alkoxy-1H-pyrazol-1-yl)pyrimidine derivatives as inhibitors of human dihydroorotate dehydrogenase (DHODH). J Med Chem. 2015 Jan 22;58(2):860-77.

Chemical & Physical Properties

[ Molecular Formula ]:
C21H24N4O2

[ Molecular Weight ]:
364.44

Related Compounds