HIV-1 integrase inhibitor 4

Names

[ CAS No. ]:
1638504-66-1

[ Name ]:
HIV-1 integrase inhibitor 4

Biological Activity

[Description]:

HIV-1 integrase inhibitor 4 is a HIV-1 integrase strand transfer (INST) inhibitor with an IC50 of 3.7 nM.

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> HIV Integrase
Signaling Pathways >> Anti-infection >> HIV
Research Areas >> Infection

[Target]

IC50: 3.7 nM (INST)[1]


[In Vitro]

HIV-1 integrase inhibitor 4 (compound 4f) is a HIV-1 integrase strand transfer (INST) inhibitor with an IC50 of 3.7 nM. HIV-1 integrase inhibitor 4 shows potent activity against recombinant HIV IN in biochemical assays and good efficacy in assays done in cell culture against a broad panel of viral mutants carrying the major RAL and DTG IN resistance mutations[1].

[References]

[1]. Zhao XZ, et al. HIV-1 Integrase Strand Transfer Inhibitors with Reduced Susceptibility to Drug Resistant MutantIntegrases. ACS Chem Biol. 2016 Apr 15;11(4):1074-81.


[Related Small Molecules]

Cenicriviroc | Ebselen | Triciribine | Raltegravir (potassium salt) | Tipranavir | DELAVIRDINE MESYLATE | Bictegravir | TAK-779 | Betulinic acid | Nelfinavir mesylate | Cabotegravir | nevirapine | Zidovudine | Celgosivir (hydrochloride)

Chemical & Physical Properties

[ Molecular Formula ]:
C24H20F2N4O5S

[ Molecular Weight ]:
514.50

[ Storage condition ]:
2-8℃

Related Compounds