HIV-1 Integrase inhibitor GS-B

Names

[ Name ]:
HIV-1 Integrase inhibitor GS-B

Biological Activity

[Description]:

HIV-1 Integrase inhibitor GS-B (GS-B) is a novel non-catalytic site integrase inhibitor of HIV-1 integrase (IN), inhibits the interaction between LEDGF IBD and IN with IC50 of 8.1 nM.GS-B displays antiviral potency in MT-4, MT-2, and human PBMCs with EC50 values of 18, 10, and 21 nM, respectively.

[References]

1. Manuel Tsiang, et al. J Biol Chem. 2012 Jun 15;287(25):21189-203. 2. Mini Balakrishnan, et al. PLoS One. 2013 Sep 9;8(9):e74163. 3. Yoshitsugu Ohata, et al. J Virol. 2022 Jan 19;JVI0184321.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₆H₂₈FNO₄

[ Molecular Weight ]:
437.511

Related Compounds

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