STAT6-IN-1

Names

[ Name ]:
STAT6-IN-1

Biological Activity

[Description]:

STAT6-IN-1 (compound 19a) is a STAT6 inhibitor with a high affinity for the SH2 domain of STAT6 (IC50=0.028 µM). STAT6-IN-1 can be used in studies of allergic lung disease, allergic rhinitis, chronic obstructive pulmonary disease or cancer[1][2].

[Related Catalog]:

Signaling Pathways >> Stem Cell/Wnt >> STAT

Research Areas >> Cancer

Signaling Pathways >> JAK/STAT Signaling >> STAT

Research Areas >> Inflammation/Immunology

[Target]

IC50: 0.028 µM (SH2)[1].

[References]

[1]. Mandal PK, et al. Targeting the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 6 (STAT6) with Cell-Permeable, Phosphatase-Stable Phosphopeptide Mimics Potently Inhibits Tyr641 Phosphorylation and Transcriptional Activity. J Med Chem. 2015 Nov 25;58(22):8970-84.

[2]. John S, et al. Stat6 inhibitors. Patent WO2014182928A2.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₃H₃₇IN₃O₇P

[ Molecular Weight ]:
745.54

Related Compounds

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