1637532-68-3

1637532-68-3 structure

Name: STAT6-IN-1
Chemical Name: STAT6-IN-1
CAS Number: 1637532-68-3
Molecular Formula: C₃₃H₃₇IN₃O₇P
Molecular Weight: 745.54
Catalog: Signaling Pathways JAK/STAT Signaling STAT
Create Date: 2022-10-15 11:04:36
Modify Date: 2024-04-05 18:07:39
STAT6-IN-1 (compound 19a) is a STAT6 inhibitor with a high affinity for the SH2 domain of STAT6 (IC50=0.028 µM). STAT6-IN-1 can be used in studies of allergic lung disease, allergic rhinitis, chronic obstructive pulmonary disease or cancer[1][2].

Name	STAT6-IN-1

Description	STAT6-IN-1 (compound 19a) is a STAT6 inhibitor with a high affinity for the SH2 domain of STAT6 (IC50=0.028 µM). STAT6-IN-1 can be used in studies of allergic lung disease, allergic rhinitis, chronic obstructive pulmonary disease or cancer[1][2].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> STAT Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> STAT Research Areas >> Inflammation/Immunology
Target	IC50: 0.028 µM (SH2)[1].
References	[1]. Mandal PK, et al. Targeting the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 6 (STAT6) with Cell-Permeable, Phosphatase-Stable Phosphopeptide Mimics Potently Inhibits Tyr641 Phosphorylation and Transcriptional Activity. J Med Chem. 2015 Nov 25;58(22):8970-84. [2]. John S, et al. Stat6 inhibitors. Patent WO2014182928A2.

Molecular Formula	C₃₃H₃₇IN₃O₇P
Molecular Weight	745.54