CPI-4203

Names

[ CAS No. ]:
1628214-07-2

[ Name ]:
CPI-4203

[Synonym ]:
6-Ethyl-5-(2-methylphenyl)-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile
Pyrazolo[1,5-a]pyrimidine-3-carbonitrile, 6-ethyl-4,7-dihydro-5-(2-methylphenyl)-7-oxo-

Biological Activity

[Description]:

CPI-4203 is a potent KDM5A inhibitor with an IC50 of 250 nM. CPI-4203 is competitive with 2-oxoglutarate (2-OG). CPI-4203 is structurally related to CPI-455 (HY-100421) but is less potent[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Epigenetics >> Histone Demethylase

[Target]

IC50: 250 nM (KDM5A)[1]


[References]

[1]. Vinogradova M, et al. An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells. Nat Chem Biol. 2016 Jul;12(7):531-8.  

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
499.4±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C16H14N4O

[ Molecular Weight ]:
278.309

[ Flash Point ]:
255.8±31.5 °C

[ Exact Mass ]:
278.116760

[ LogP ]:
2.58

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.670

Related Compounds