1628214-07-2

1628214-07-2 structure

Name: CPI-4203
Chemical Name: 6-Ethyl-5-(2-methylphenyl)-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile
CAS Number: 1628214-07-2
Molecular Formula: C₁₆H₁₄N₄O
Molecular Weight: 278.309
Catalog: Signaling Pathways Epigenetics Histone Demethylase
Create Date: 2018-06-08 14:38:53
Modify Date: 2025-09-18 08:49:30
CPI-4203 is a potent KDM5A inhibitor with an IC50 of 250 nM. CPI-4203 is competitive with 2-oxoglutarate (2-OG). CPI-4203 is structurally related to CPI-455 (HY-100421) but is less potent[1].

Name	6-Ethyl-5-(2-methylphenyl)-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile
Synonyms	6-Ethyl-5-(2-methylphenyl)-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile Pyrazolo[1,5-a]pyrimidine-3-carbonitrile, 6-ethyl-4,7-dihydro-5-(2-methylphenyl)-7-oxo-

Description	CPI-4203 is a potent KDM5A inhibitor with an IC50 of 250 nM. CPI-4203 is competitive with 2-oxoglutarate (2-OG). CPI-4203 is structurally related to CPI-455 (HY-100421) but is less potent[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Histone Demethylase
Target	IC50: 250 nM (KDM5A)[1]
References	[1]. Vinogradova M, et al. An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells. Nat Chem Biol. 2016 Jul;12(7):531-8.