P2X7 receptor antagonist-3

Names

[ CAS No. ]:
1627900-92-8

[ Name ]:
P2X7 receptor antagonist-3

Biological Activity

[Description]:

P2X7 receptor antagonist-3 is a potent P2X7 receptor antagonist with P2X7R IC50 values of 4.2 nM in humans and 6.8 nM in rats[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> P2X Receptor
Research Areas >> Neurological Disease

[Target]

hP2X7R:4.2 nM (IC50)

rP2X7R:6.8 nM (IC50)


[References]

[1]. Brad M Savall, et al. Synthesis, SAR, and Pharmacological Characterization of Brain Penetrant P2X7 Receptor Antagonists. ACS Med Chem Lett. 2015 Apr 24;6(6):671-6.  

Chemical & Physical Properties

[ Molecular Formula ]:
C17H12ClF3N6O

[ Molecular Weight ]:
408.76

Related Compounds