Antitumor agent-63

Names

[ CAS No. ]:
1627600-90-1

[ Name ]:
Antitumor agent-63

Biological Activity

[Description]:

Antitumor agent-63 (Compound 40), a 20 (S)-O-linked camptothecin (CPT) glycoconjugate, is an antitumor agent without toxicity towards normal cells. Antitumor agent-63 shows high stability and very weak direct topoisomerase I (Topo I) inhibition[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase

[Target]

Top1


[In Vitro]

Antitumor agent-63 (Compound 40) shows cytotoxicity activities with IC50 values of 1.2, 0.8, 30.5 and >100 µM against HepG2, HCT-116, SW1990 and HEK-293, respectively[1].

[References]

[1]. Li M, et al. Oligosaccharide-camptothecin conjugates as potential antineoplastic drugs: Design, synthesis and biological evaluation. Eur J Med Chem. 2020 Sep 15;202:112509.

Chemical & Physical Properties

[ Molecular Formula ]:
C38H46N4O18

[ Molecular Weight ]:
846.79

Related Compounds