CDP 840 hydrochloride

Names

[ Name ]:
CDP 840 hydrochloride

Biological Activity

[Description]:

CDP-840 (GR259653X) is a potent, selective and orally active phosphodiesterase IV (PDE IV) inhibitor. CDP-840 inhibits antigen-induced early and late phase bronchoconstriction in conscious squirrel monkeys[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE)

Research Areas >> Inflammation/Immunology

[Target]

PDE4

[References]

[1]. Jones TR, et al. Effects of a selective phosphodiesterase IV inhibitor (CDP-840) in a leukotriene-dependent non-human primate model of allergic asthma. Can J Physiol Pharmacol. 1998 Feb;76(2):210-7.

Chemical & Physical Properties

[ Density]:
1.122g/cm3

[ Boiling Point ]:
489.9ºC at 760 mmHg

[ Molecular Formula ]:
C₂₅H₂₇NO₂

[ Molecular Weight ]:
373.49

[ Flash Point ]:
174.3ºC

[ Exact Mass ]:
373.20400

[ PSA ]:
31.35000

[ LogP ]:
5.78620

[ Vapour Pressure ]:
2.88E-09mmHg at 25°C

[ Index of Refraction ]:
1.591

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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