EDTA, AM

Names

[ CAS No. ]:
162303-59-5

[ Name ]:
EDTA, AM

[Synonym ]:
Acetoxymethyl 8,11-bis[2-(acetoxymethoxy)-2-oxoethyl]-2,6-dioxo-3,5-dioxa-8,11-diazatridecan-13-oate

Biological Activity

[Description]:

EDTA-AM (ethylenediaminetetraacetic acid, acetoxymethyl ester) is the membrane-permeant form of the metal chelator EDTA (HY-Y0682). Live cells passively load EDTA-AM by incubating with EDTA-AM. Once internalized, cytoplasmic esterase decomposes AM esters, releasing the active ligand EDTA, which isolates metal ions within the cell. EDTA-AM induces an arrest of mitotic progression and chromosome decondensation[1][2].

[Related Catalog]:

Research Areas >> Others

[References]

[1]. Watkins CS, et.al. Effects on K+ currents in rat cerebellar granule neurones of a membrane-permeable analogue of the calcium chelator BAPTA. Br J Pharmacol. 1996 Aug;118(7):1772-8.  

[2]. Maeshima K, et.al. A Transient Rise in Free Mg2+Ions Released from ATP-Mg Hydrolysis Contributes to Mitotic Chromosome Condensation. Curr Biol. 2018 Feb 5;28(3):444-451.e6.  

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
607.0±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C22H32N2O16

[ Molecular Weight ]:
580.49

[ Flash Point ]:
320.9±31.5 °C

[ Exact Mass ]:
580.175171

[ LogP ]:
2.16

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.491

Related Compounds