2-Chloroethanesulfonyl chloride
Names
[ CAS No. ]:
1622-32-8
[ Name ]:
2-Chloroethanesulfonyl chloride
[Synonym ]:
Ethanesulfonylchloride, 2-chloro-
2-Chloroethanesulfonylchloride
Ethanesulfonyl chloride, 2-chloro-
2-CHLOROETHANE SULFOCHLORIDE
EINECS 216-594-1
MFCD00007461
2-Chloroethanesulfonyl chloride
2-Chloroethylsulfonyl chloride
Chemical & Physical Properties
[ Density]:
1.5±0.1 g/cm3
[ Boiling Point ]:
202.4±13.0 °C at 760 mmHg
[ Molecular Formula ]:
C2H4Cl2O2S
[ Molecular Weight ]:
163.023
[ Flash Point ]:
76.2±19.8 °C
[ Exact Mass ]:
161.930908
[ PSA ]:
42.52000
[ LogP ]:
0.83
[ Vapour Pressure ]:
0.4±0.4 mmHg at 25°C
[ Index of Refraction ]:
1.477
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- KI8060000
- CHEMICAL NAME :
- Ethanesulfonyl chloride, 2-chloro-
- CAS REGISTRY NUMBER :
- 1622-32-8
- BEILSTEIN REFERENCE NO. :
- 1751202
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 7
- MOLECULAR FORMULA :
- C2-H4-Cl2-O2-S
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 240 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 15(6),59,1971
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 420 mg/m3/4H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 15(6),59,1971
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 250 mg/m3/4H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 15(6),59,1971 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 10 mg/m3/4H/17W-I
- TOXIC EFFECTS :
- Brain and Coverings - recordings from specific areas of CNS Vascular - BP lowering not characterized in autonomic section
- REFERENCE :
- GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 15(6),59,1971
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 10 mg/m3/4H/17W-I
- TOXIC EFFECTS :
- Vascular - BP lowering not characterized in autonomic section Liver - liver function tests impaired Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
- REFERENCE :
- GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 15(6),59,1971 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 0.3 mg/m3;Skin JAN 1993
Safety Information
[ Symbol ]:
GHS05, GHS06
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H301-H314-H330
[ Precautionary Statements ]:
P260-P280-P284-P301 + P310-P305 + P351 + P338-P310
[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
T+: Very toxic;
[ Risk Phrases ]:
R22
[ Safety Phrases ]:
S26-S28-S36/37/39-S45
[ RIDADR ]:
UN 3390 6.1/PG 1
[ WGK Germany ]:
3
[ RTECS ]:
KI8060000
[ Packaging Group ]:
II
[ Hazard Class ]:
8
[ HS Code ]:
2904909090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2904909090
[ Summary ]:
HS:2904909090 sulphonated, nitrated or nitrosated derivatives of hydrocarbons, whether or not halogenated VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%
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Thermal and high pressure intramolecular Diels-Alder reaction of vinylsulfonamides.Nat. Protoc. 1(6) , 3076-87, (2006)
Vinylsulfonamides with a furan, carbocyclic, semicyclic or acyclic 1,3-diene moiety are synthetized via a domino elimination-amidation reaction of 2-chloroethanesulfonyl chloride. Intramolecular Diels...