TD-1

Hemoglobin modulator TD-1 (TD-1) is a novel allosteric effector of hemoglobin that increases hemoglobin oxygen affinity and reduces SS erythrocyte sickling; increases the oxygen affinity of sickle hemoglobin and inhibits in vitro hypoxia-induced sickling of red blood cells in patients with sickle cell disease without causing hemolysis; a novel lead molecule for the treatment of patients with sickle cell disease.

References 1. Nakagawa A, et al. ACS Chem Biol. 2014 Oct 17;9(10):2318-25. View Related Products by Target Other Targets