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Transdermal Peptide

Names

[ CAS No. ]:
918629-48-8

[ Name ]:
Transdermal Peptide

[Synonym ]:
Transdermal Peptide
L-Alanyl-L-cysteinyl-L-seryl-L-seryl-L-seryl-L-prolyl-L-seryl-L-lysyl-L-histidyl-L-cysteinylglycine

Biological Activity

[Description]:

Transdermal Peptide is a 11-amino acid peptide, binds to Na+/K+-ATPase beta-subunit (ATP1B1), and enhances the transdermal delivery of many macromolecules.

[Related Catalog]:

Signaling Pathways >> Others >> Others
Peptides
Research Areas >> Others

[In Vitro]

Transdermal Peptide (TD1) binds to ATP1B1, and mainly interacts with the C-terminus of ATP1B1 in yeast and mammalian cells. The interaction affects the expression and localization of ATP1B1 and epidermal structure, but can be antagonized by the exogenous competitor ATP1B1 or be inhibited by ouabain. Inhibition of Transdermal Peptide binding to ATP1B1 causes decreased delivery of macromolecular drugs across the skin[1].

[References]

[1]. Wang C, et al. Role of the Na(+)/K(+)-ATPase beta-subunit in peptide-mediated transdermal drug delivery. Mol Pharm. 2015 Apr 6;12(4):1259-67.


[Related Small Molecules]

Captisol | Cyclosporin A | H2DCFDA | 0MPTP hydrochloride | GW4869 | Etomoxir | TD139 | Mitoquinone mesylate | GSK2795039 | JC-1 | BAPTA-AM | AP 20187 | Setanaxib (GKT137831) | D-Luciferin | Crotaline

Chemical & Physical Properties

[ Density]:
1.450±0.06 g/cm3

[ Molecular Formula ]:
C40H66N14O16S2

[ Molecular Weight ]:
1063.17000

[ Exact Mass ]:
1062.42000

[ PSA ]:
558.75000

[ Water Solubility ]:
Very soluble (1000 g/L) (25 ºC)

Related Compounds