PF-06372865

Names

[ Name ]:
PF-06372865

Biological Activity

[Description]:

PF-06372865 is a novel potent, α2/3 functionally selective GABAA receptor positive allosteric modulator; exhibits functional selectivity for receptors containing α2/3/5 subunits, with significant positive allosteric modulation (90-140%) but negligible activity (<20%) at GABAA receptors containing α1 subunits; demonstrates a robust increase in saccadic peak velocity, increases in beta frequency qEEG and a slight saturating increase in body sway in clinical trials. Epilepsy Phase 1 Clinical

[References]

References 1. Nickolls SA, et al. Br J Pharmacol. 2018 Feb;175(4):708-725. View Related Products by Target GABA Receptor Epilepsy

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₂₁FN₄O₃S

[ Molecular Weight ]:
440.493

Related Compounds

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