1614245-70-3
1614245-70-3 structure
- Name: PF-06372865
- Chemical Name: PF-06372865
- CAS Number: 1614245-70-3
- Molecular Formula: C22H21FN4O3S
- Molecular Weight: 440.493
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel GABA Receptor
- Create Date: 2020-01-16 01:01:32
- Modify Date: 2024-02-28 10:13:30
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PF-06372865 is a novel potent, α2/3 functionally selective GABAA receptor positive allosteric modulator; exhibits functional selectivity for receptors containing α2/3/5 subunits, with significant positive allosteric modulation (90-140%) but negligible activity (<20%) at GABAA receptors containing α1 subunits; demonstrates a robust increase in saccadic peak velocity, increases in beta frequency qEEG and a slight saturating increase in body sway in clinical trials. Epilepsy Phase 1 Clinical
| Name | PF-06372865 |
|---|
| Description | PF-06372865 is a novel potent, α2/3 functionally selective GABAA receptor positive allosteric modulator; exhibits functional selectivity for receptors containing α2/3/5 subunits, with significant positive allosteric modulation (90-140%) but negligible activity (<20%) at GABAA receptors containing α1 subunits; demonstrates a robust increase in saccadic peak velocity, increases in beta frequency qEEG and a slight saturating increase in body sway in clinical trials. Epilepsy Phase 1 Clinical |
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| References | References 1. Nickolls SA, et al. Br J Pharmacol. 2018 Feb;175(4):708-725. View Related Products by Target GABA Receptor Epilepsy |
| Molecular Formula | C22H21FN4O3S |
|---|---|
| Molecular Weight | 440.493 |