Cholesterol 24-hydroxylase-IN-1

Names

[ Name ]:
Cholesterol 24-hydroxylase-IN-1

Biological Activity

[Description]:

Cholesterol 24-hydroxylase-IN-1 (compound 17) is a potent, orally active, and highly selective cholesterol 24-hydroxylase (CH24H or CYP46A1) inhibitor (IC50=8.5 nM). Cholesterol 24-hydroxylase-IN-1 can cross blood-brain barrier[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450

Research Areas >> Neurological Disease

[References]

[1]. Kajita Y, et al. Discovery of Novel 3-Piperidinyl Pyridine Derivatives as Highly Potent and Selective Cholesterol 24-Hydroxylase (CH24H) Inhibitors. J Med Chem. 2022;65(4):3343-3358.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₂₃N₅O

[ Molecular Weight ]:
313.40

Related Compounds

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