PF-06250112

Names

[ Name ]:
PF-06250112

Biological Activity

[Description]:

PF-06250112 is a potent, highly selective, orally bioavailable BTK inhibitor with an IC50 of 0.5 nM, shows inhibitory effect toward BMX nonreceptor tyrosine kinase and TEC with IC50s of 0.9 nM and 1.2 nM, respectively[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Btk

[Target]

IC50: 0.5 nM (BTK), 0.9 nM (BMX), 1.2 nM (TEC)[1]

[References]

[1]. Rankin AL, et al. Selective inhibition of BTK prevents murine lupus and antibody-mediated glomerulonephritis. J Immunol. 2013 Nov 1;191(9):4540-50.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₂₀F₂N₆O₂

[ Molecular Weight ]:
438.43

Related Compounds

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