1609465-89-5

1609465-89-5 structure

Name: PF-06250112
Chemical Name: PF-06250112
CAS Number: 1609465-89-5
Molecular Formula: C₂₂H₂₀F₂N₆O₂
Molecular Weight: 438.43
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK Btk
Create Date: 2019-06-17 17:59:11
Modify Date: 2024-01-15 17:59:55
PF-06250112 is a potent, highly selective, orally bioavailable BTK inhibitor with an IC50 of 0.5 nM, shows inhibitory effect toward BMX nonreceptor tyrosine kinase and TEC with IC50s of 0.9 nM and 1.2 nM, respectively[1].

Name	PF-06250112

Description	PF-06250112 is a potent, highly selective, orally bioavailable BTK inhibitor with an IC50 of 0.5 nM, shows inhibitory effect toward BMX nonreceptor tyrosine kinase and TEC with IC50s of 0.9 nM and 1.2 nM, respectively[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Btk
Target	IC50: 0.5 nM (BTK), 0.9 nM (BMX), 1.2 nM (TEC)[1]
References	[1]. Rankin AL, et al. Selective inhibition of BTK prevents murine lupus and antibody-mediated glomerulonephritis. J Immunol. 2013 Nov 1;191(9):4540-50.

Molecular Formula	C₂₂H₂₀F₂N₆O₂
Molecular Weight	438.43