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2,3-Dihydro-3α-methoxynimbolide

Names

[ CAS No. ]:
1607828-35-2

[ Name ]:
2,3-Dihydro-3α-methoxynimbolide

[Synonym ]:
2H,3H-Cyclopenta[d]naphtho[2,3-b:1,8-b'c']difuran-6-acetic acid, 8-(3-furanyl)-2a,4,5,5a,6,6a,8,9,9a,10a,10b,10c-dodecahydro-3-methoxy-2a,5a,6a,7-tetramethyl-2,5-dioxo-, methyl ester, (2aS,3R,5aR,6S,6aR,8R,9aR,10aS,10bR,10cR)-
Methyl [(2aS,3R,5aR,6S,6aR,8R,9aR,10aS,10bR,10cR)-8-(3-furyl)-3-methoxy-2a,5a,6a,7-tetramethyl-2,5-dioxo-2a,4,5,5a,6,6a,8,9,9a,10a,10b,10c-dodecahydro-2H,3H-cyclopenta[b]furo[2',3',4':4,5]naphtho[2,3-d]furan-6-yl]acetate

Biological Activity

[Description]:

2,3-Dihydro-3α-methoxynimbolide is a limonoid compound isolated from the extracts of bark, leaves, roots, and seeds of Azadirachta indica A. Juss. var. siamensis Valeton. 2,3-Dihydro-3α-methoxynimbolide exhibits potent cyto-toxicities against one or more cell lines. 2,3-Dihydro-3α-methoxynimbolide activates caspases-3, -8, and -9, while increases the ratio of Bax/Bcl-2. 2,3-Dihydro-3α-methoxynimbolide induces apoptosis via both mitochondrial and death receptor pathways in AZ521[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Others

[References]

[1]. Manosroi A, et al. Limonoids from Azadirachta indica var. siamensis extracts and their cytotoxic and melanogenesis-inhibitory activities. Chem Biodivers. 2014;11(4):505-531.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
617.7±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C28H34O8

[ Molecular Weight ]:
498.56

[ Flash Point ]:
327.3±31.5 °C

[ Exact Mass ]:
498.225372

[ LogP ]:
2.28

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.577

[ Storage condition ]:
2-8℃

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds