1-Acetylindoline

Names

[ Name ]:
1-Acetylindoline

[Synonym ]:
N-Acetylindoline
1-(Indolin-1-yl)ethanone
1-(2,3-Dihydro-1H-indol-1-yl)ethanone
1-(2,3-dihydroindol-1-yl)ethanone
Ethanone, 1-(2,3-dihydro-1H-indol-1-yl)-
MFCD00022908
N-Acetyl indoline

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
355.1±21.0 °C at 760 mmHg

[ Melting Point ]:
102-104 °C(lit.)

[ Molecular Formula ]:
C₁₀H₁₁NO

[ Molecular Weight ]:
161.200

[ Flash Point ]:
174.5±13.3 °C

[ Exact Mass ]:
161.084061

[ PSA ]:
20.31000

[ LogP ]:
1.76

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.576

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NM1892500

CHEMICAL NAME :: Indoline, 1-acetyl-

CAS REGISTRY NUMBER :: 16078-30-1

BEILSTEIN REFERENCE NO. :: 0129366

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C10-H11-N-O

MOLECULAR WEIGHT :: 161.22

WISWESSER LINE NOTATION :: T56 BNT&J BV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 204 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 20,1448,1977

Safety Information

[ Hazard Codes ]:
Xn

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
NM1892500

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

The synthesis of 5-and 7-acetylindole derivatives. I: The photochemical rearrangement of 1-acetylindoline. Akagi M and Ozaki K.

Heterocycles 26(!) , 61-64, (1987)

Highly Convenient and Large Scale Synthesis of 5-chloroindole and its 3-substituted Analogues Keetha L, et al.

J. Korean Chem. Soc. 55(2) , (2011)

Reduction of amides with silanes catalyzed by MoO₂Cl₂. Fernandes AC and Romão CC.

J. Mol. Catal. A: Chem. 272(1) , 60-63., (2007)