9H-Purine, 9-(2-deoxy-b-D-erythro-pentofuranosyl)-6-methyl-

Names

[ Name ]:
9H-Purine, 9-(2-deoxy-b-D-erythro-pentofuranosyl)-6-methyl-

[Synonym ]:
6-methylpurine-2'-deoxyriboside
9-(2-deoxypentopyranosyl)-9h-purin-6-amine

Biological Activity

[Description]:

(2R,3S,5R)-2-(hydroxymethyl)-5-(6-methyl-9H-purin-9-yl)tetrahydrofuran-3-ol (9-(2-Deoxy-beta-D-ribofuranosyl)-6-methylpurine) is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

Research Areas >> Others

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Density]:
1.67g/cm3

[ Boiling Point ]:
544.7ºC at 760mmHg

[ Molecular Formula ]:
C₁₂H₁₅N₃O₃

[ Molecular Weight ]:
249.27

[ Flash Point ]:
283.2ºC

[ Exact Mass ]:
250.10700

[ PSA ]:
93.29000

[ Vapour Pressure ]:
1.07E-12mmHg at 25°C

[ Index of Refraction ]:
1.762

Safety Information

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%