Sabcomeline

Names

[ Name ]:
Sabcomeline

[Synonym ]:
Sabcomeline
Sabcomeline [INN:BAN]

Biological Activity

[Description]:

Sabcomeline (SB-202026) is a potent and functionally selective muscarinic M1 receptor partial agonist that improve cognition. Sabcomeline can be used for Alzheimer's disease research[1][2].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> mAChR

Signaling Pathways >> GPCR/G Protein >> mAChR

Research Areas >> Neurological Disease

[Target]

Muscarinic M1 receptor[1][2]

[References]

[1]. Hosoi R, et al. Effect of sabcomeline on muscarinic and dopamine receptor binding in intact mouse brain. Ann Nucl Med. 2003;17(2):123-130.

[2]. Hatcher JP, et al. Sabcomeline (SB-202026), a functionally selective M1 receptor partial agonist, reverses delay-induced deficits in the T-maze. Psychopharmacology (Berl). 1998;138(3-4):275-282.

Chemical & Physical Properties

[ Density]:
1.25

[ Boiling Point ]:
278ºC

[ Molecular Formula ]:
C₁₀H₁₅N₃O

[ Molecular Weight ]:
193.24600

[ Flash Point ]:
122ºC

[ Exact Mass ]:
193.12200

[ PSA ]:
48.62000

[ LogP ]:
0.79208

Safety Information

[ HS Code ]:
2933990090

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%