N-Phenylsulfamide

Names

[ Name ]:
N-Phenylsulfamide

[Synonym ]:
aniline sulfonic acid amide
Phenyl-sulfamid
4-sulfamoylaminobenzene
sulfamoylphenylamide
phenylsulfamide
Schwefelsaeure-amid-anilid
N-phenyl sulfamide
Sulfamide,phenyl

Biological Activity

[Description]:

Phenylsulfamide (Compound 10) is a human carbonic anhydrase-II (hCA-II) inhibitor with a Kd of 45.50 μM and a Ki of 79.60 μM[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Metabolic Enzyme/Protease >> Carbonic Anhydrase

[Target]

hCA II:45.50 μM (Kd)

hCA II:79.60 μM (Ki)

[References]

[1]. Klinger AL, et al. Inhibition of carbonic anhydrase-II by sulfamate and sulfamide groups: an investigation involving direct thermodynamic binding measurements. J Med Chem. 2006 Jun 15;49(12):3496-500.

Chemical & Physical Properties

[ Molecular Formula ]:
C₆H₈N₂O₂S

[ Molecular Weight ]:
172.20500

[ Exact Mass ]:
172.03100

[ PSA ]:
80.57000

[ LogP ]:
2.15610

Synthetic Route

Click to get detail synthetic route

Related Compounds

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