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Hoechst 33342 analog trihydrochloride

Names

[ CAS No. ]:
159277-19-7

[ Name ]:
Hoechst 33342 analog trihydrochloride

[Synonym ]:
N,N-bis(2-chloroethyl)-4-{3-[6-(4-methylpiperazin-1-yl)-1H,3'H-2,5'-bibenzimidazol-2'-yl]propyl}aniline trihydrochloride
Benzenamine,N,N-bis(2-chloroethyl)-4-(3-(5-(4-methyl-1-piperazinyl)(2,5'-bi-1H-benzimidazol)-2'-yl)propyl)-,hydrochloride,hydrate (1:3:3)
MGB2 compound
N,N-bis(2-chloroethyl)-4-[3-[6-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-benzimidazol-2-yl]propyl]aniline trihydrochloride

Biological Activity

[Description]:

Hoechst 33342 analog trihydrochloride is an anglog of Hoechst 33342, which is a DNA minor groove binder used fluorochrome for visualizing cellular DNA[1].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Others >> Others

[In Vitro]

Hoechst 33342 binds to adenine-thymine-rich regions of DNA in the minor groove. Hoechst 33342 labels nuclear DNA of cells grown in culture. Image the cells (λex~353 nm, λem~483 nm for Hoechst 33342)[1].

[References]

[1]. Chazotte B. Labeling nuclear DNA with hoechst 33342. Cold Spring Harb Protoc. 2011 Jan 1;2011(1):pdb.prot5557.

Chemical & Physical Properties

[ Boiling Point ]:
841.2ºC at 760mmHg

[ Molecular Formula ]:
C32H40Cl5N7

[ Molecular Weight ]:
699.97200

[ Exact Mass ]:
697.17900

[ PSA ]:
67.08000

[ LogP ]:
8.72620

[ Vapour Pressure ]:
1.59E-28mmHg at 25°C

Related Compounds