Tamoxifen-d5

Names

[ Name ]:
Tamoxifen-d5

[Synonym ]:
(E/Z)-Mammaton-d5
Novaldex-d5
Z-Tamoxifen-d5
Mammaton-d5
(E/Z)-Novaldex-d5
(E/Z)-Tamoxifen-d5
trans-Tamoxifen-d5
Tamoxifen-d5

Biological Activity

[Description]:

Tamoxifen-d5 (ICI 47699-d5) is a deuterium labeled Tamoxifen. Tamoxifen (ICI 47699) is a selective estrogen receptor modulator (SERM). Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Estrogen Receptor/ERR

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> HSP

Signaling Pathways >> Autophagy >> Autophagy

Signaling Pathways >> Cell Cycle/DNA Damage >> HSP

[Target]

Estrogen receptor

HSP90

[References]

[1]. Osborne CK. Tamoxifen in the treatment of breast cancer. N Engl J Med. 1998 Nov 26;339(22):1609-18.

[2]. Zhao R, et al. Tamoxifen enhances the Hsp90 molecular chaperone ATPase activity. PLoS One. 2010 Apr 1;5(4):e9934.

Chemical & Physical Properties

[ Density]:
1.057g/cm3

[ Boiling Point ]:
482.3ºC at 760mmHg

[ Molecular Formula ]:
C₂₆H₂₄D₅NO

[ Molecular Weight ]:
376.54500

[ Flash Point ]:
140ºC

[ Exact Mass ]:
376.25600

[ PSA ]:
12.47000

[ LogP ]:
5.99610

[ Vapour Pressure ]:
1.85E-09mmHg at 25°C

[ Index of Refraction ]:
1.582

Related Compounds

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