1-Ethynylnaphthalene

Names

[ Name ]:
1-Ethynylnaphthalene

[Synonym ]:
1-(ethynyl)naphthalene
1-naphthalene-acetylene
Naphthalene,1-ethynyl
naphthylacetylene
(1-naphthyl)acetylene
MFCD02093737
ethynyl-naphthalene

Biological Activity

[Description]:

1-Ethynylnaphthalene is a selective inhibitor of cytochrome P450 1B1.

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450

Research Areas >> Cancer

[Target]

P450 1B1[1]

[In Vitro]

1-Ethynylnaphthalene, selective inhibitor of cytochrome P450 IB1, does not affect 2-hydroxylation but inhibits 4-hydroxylation by 38%. At higher concentrations, 1-Ethynylnaphthalene inhibits 2-hydroxylation of 2-Hydroxylation of estradiol (E2) by ~30% and 4-hydroxylation of E2 by up to 80%[1].

[References]

[1]. Liehr JG, et al. 4-Hydroxylation of estradiol by human uterine myometrium and myoma microsomes: implications for the mechanism of uterine tumorigenesis. Proc Natl Acad Sci U S A. 1995 Sep 26;92(20):9220-4.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.070 g/mL at 25ºC(lit.)

[ Boiling Point ]:
270.4ºC at 760 mmHg

[ Molecular Formula ]:
C₁₂H₈

[ Molecular Weight ]:
152.19200

[ Flash Point ]:
106.3ºC

[ Exact Mass ]:
152.06300

[ LogP ]:
2.82110

[ Vapour Pressure ]:
0.0114mmHg at 25°C

[ Index of Refraction ]:
n20/D 1.6500(lit.)

[ Storage condition ]:
2-8℃

Safety Information

[ Risk Phrases ]:
R10

[ Safety Phrases ]:
16

[ RIDADR ]:
UN 1993 3

[ HS Code ]:
2902909090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2902909090

[ Summary ]:
2902909090 other aromatic hydrocarbons。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:2.0%。General tariff:30.0%